The cancer-associated fibroblasts interact with malignant T cells in mycosis fungoides and promote the disease progression.

ABSTRACT:

Background

Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of T-cell lymphomas characterized with the presence of clonal malignant T cells. Mycosis fungoides (MF) is the most common type of CTCL. However, the pathogenesis of MF and the role of the tumor microenvironment (TME) remain unclear.

Methods

We performed single-cell RNA sequencing on tumor and adjacent normal tissues and peripheral blood mononuclear cell (PBMC) from patients with advanced MF and healthy control (HC). We compared skin lesions in different stages within the same patient to overcome inter-individual variability.

Results

The malignant clones displayed dual phenotypes characterized with tissue-resident memory T cells (TRMs) and central memory T cells (TCMs). We supposed that the tumor cel

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC11830738 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature