Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice.

ABSTRACT:

Instruction

Accumulating evidence has shown that proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with inflammation in the vascular system. However, the roles of PCSK9 in hepatic inflammation remain unclear. Because PCSK9 is mainly expressed in the liver and modulates lipid uptake through low-density lipoprotein receptor family members, the present study aimed to elucidate the effect of conditional knockdown of hepatic PCSK9 on hyperlipidemia-induced inflammation and the underlying mechanisms of action.

Methods

PCSK9flox/flox mice were bred with ALB-Cre⁺ mice to obtain hepatic PCSK9 ^(-/-) , PCSK9 ^(+/-) , and PCSK9 ^(+/+) mice. These mice were fed with a high-fat diet for 9 weeks to induce infl

SUBMITTER: Zhang XY 

PROVIDER: S-EPMC11830812 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature