The association between gonadectomy and timing of gonadectomy, and the risk of canine cranial cruciate ligament disease: A systematic review and meta-analysis.

ABSTRACT:

Objective

To determine if gonadectomy in dogs is associated with the risk of cranial cruciate ligament disease (CrCLD) and to quantify the magnitude of the association.

Study design

Systematic review and meta-analysis.

Sample population

Comparative studies with gonadectomized and entire dogs, with CrCLD as an outcome measure.

Methods

A systematic search of the primary and gray literature was performed. The effect size of the outcome measure was defined as the OR and 95% CI. Subgroup analysis was performed with sex, breed, and age at gonadectomy. A pooled OR (95% CI) was generated from meta-analysis of relevant studies. Certainty in the body of evidence was rated with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework.

Res

SUBMITTER: Low D 

PROVIDER: S-EPMC11830852 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature