Cocaine to prevent bleeding during nasotracheal intubation: A systematic review.

ABSTRACT:

Background

Nasotracheal intubation is associated with a risk of epistaxis. Decongestion of the nasal mucosa reduces the risk of epistaxis, and different vasoconstrictors may be used. Cocaine has both decongestive and analgesic properties, but it also has side effects. In this systematic review, we aimed to evaluate if cocaine decreases the occurrence and severity of epistaxis when administered topically to the nasal mucosa before nasotracheal intubation.

Methods

We conducted a systematic review and meta-analysis following the PRISMA guidelines based on a predefined protocol. We included randomized clinical trials comparing nasal cocaine to active comparators or placebo for nasotracheal intubation. Two reviewers independently screened studies for eligibility and performed dat

SUBMITTER: Larsen MH 

PROVIDER: S-EPMC11830855 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature