Jiawei Kongsheng Zhenzhong Pill (JKZP) Alleviates Chronic Cerebral Hypoperfusion-Induced Hippocampal Synaptic Damage via S100A10/tPA/BDNF Pathway.

ABSTRACT:

Aims

To evaluate the effects of Jiawei Kongsheng Zhenzhong Pill (JKZP) on rats with ischemic mild cognitive impairment (MCI) and investigate the underlying mechanisms.

Methods

The components of JKZP were analyzed using Q-Orbitrap high-resolution mass spectrometry (HRMS). The MCI rat model was prepared through gradual bilateral common carotid artery occlusion (BCCAO). The cognitive function, hippocampal pathological lesions, dendritic spine damage, synapse-related, and S100 calcium-binding protein A10 (S100A10)/tissue-type plasminogen activator (tPA)/brain-derived neurotrophic factor (BDNF) pathway-associated molecules alterations were measured. Primary hippocampus neurons were subjected to oxygen-glucose deprivation/reperfusion (OGD/R) injury, and JKZP-containing serum was u

SUBMITTER: Wu Q 

PROVIDER: S-EPMC11830996 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature