Cognitive Impairment in Chronic Kidney Disease Across Different Stages: The Role of Structural and Perfusion-Driven Functional Connectivity Changes.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) is associated with cognitive impairment (CI), yet the exact pathophysiological mechanisms remain unclear. This study aims to investigate the alterations in gray matter volume (GMV) and cerebral blood flow (CBF) across CKD stages, identify co-changed brain regions, explore abnormal seed-based functional connectivity (FC) in patients with CKD, and investigate the correlation between the abnormal brain regions and neuropsychological test scores.

Methods

Two hundred and eight participants (66 healthy controls, 70 CKD Stages 1-3a, and 72 CKD Stages 3b-5) were consecutively recruited and underwent high-resolution T1-weighted imaging, arterial spin labeling, and functional MR imaging. The imaging parameters were compared among three groups,

SUBMITTER: Bai X 

PROVIDER: S-EPMC11830999 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature