Tau PET Imaging With [¹⁸F]MK-6240: Limited Affinity for Primary Tauopathies and High Specificity for Alzheimer's Disease.

ABSTRACT:

Introduction

Second-generation tau-PET tracers like [¹⁸F]MK-6240 are increasingly used both for diagnosing and quantifying Alzheimer's Disease (AD) tauopathy. However, while [¹⁸F]MK-6240 tau-PET has demonstrated excellent sensitivity for AD tauopathy, data assessing its specificity and binding in non-AD tauopathies are still scarce.

Methods

Participants were assigned to exclusive categorical diagnoses based on their amyloid (Aβ) and cognitive status. We quantified mesiotemporal (MTL) and neocortical [¹⁸F]MK-6240 tau-PET signal in 28 Aβ- cognitively impaired (CI) patients presenting various non-AD neurodegenerative disorders. Tau-PET quantifications were compared with Aβ- cognitively unimpaired (CU) subjects (n = 51) and Aβ+ CI patients (n = 7

SUBMITTER: Gerard T 

PROVIDER: S-EPMC11831001 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature