Plasma brain-derived neurotrophic factor concentrations are elevated in community-dwelling adults with sarcopenia.

ABSTRACT:

Background

The scalability of a blood-based sarcopenia assessment has generated interest in circulating markers that may enhance management strategies. Data regarding the relevance of brain derived neurotrophic factor (BDNF), a regulator of neuroplasticity, to sarcopenia in community-dwelling adults are scarce. We examined the association between plasma BDNF concentrations, sarcopenia and individual sarcopenia signatures in a well-characterised adult cohort.

Methods

Participants included 246 men and women aged 50-82 years (mean age = 63.6 years; 52% female). Muscle strength and skeletal muscle index (SMI) were assessed by hand dynamometry and dual-energy X-ray absorptiometry. Plasma BDNF concentrations were determined, in duplicate, with commercially available enzyme-linked

SUBMITTER: Pratt J 

PROVIDER: S-EPMC11831035 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature