Fecal Microbiota Transplantation Improves Cognitive Function of a Mouse Model of Alzheimer's Disease.

ABSTRACT:

Background

A growing body of evidence suggests a link between the gut microbiota and Alzheimer's disease (AD), although the underlying mechanisms remain elusive. This study aimed to investigate the impact of fecal microbiota transplantation (FMT) on cognitive function in a mouse model of AD.

Methods

Four-month-old 5 × FAD (familial Alzheimer's disease) mice underwent antibiotic treatment to deplete their native gut microbiota. Subsequently, they received FMT either weekly or every other day. After 8 weeks, cognitive function and β-amyloid (Aβ) load were assessed through behavioral testing and pathological analysis, respectively. The composition of the gut microbiota was analyzed using 16S rRNA sequencing.

Results

Initial weekly FMT failed to alleviate memory deficits

SUBMITTER: Jiang X 

PROVIDER: S-EPMC11831070 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature