Bilateral cellular flows display asymmetry prior to left-right organizer formation in amniote gastrulation.

ABSTRACT: A bilateral body plan is predominant throughout the animal kingdom. Bilaterality of amniote embryos becomes recognizable as midline morphogenesis begins at gastrulation, bisecting an embryonic field into the left and right sides, and left-right (LR) asymmetry patterning follows. While a series of laterality genes expressed after the LR compartmentalization has been extensively studied, the laterality patterning prior to and at the initiation of midline morphogenesis has remained unclear. Here, through a biophysical quantification in a high spatial and temporal resolution, applied to a chick model system, we show that a large-scale bilateral counterrotating cellular flow, termed "polonaise movements", display LR asymmetries in early gastrulation. This cell movement starts prior to the forma

SUBMITTER: Asai R 

PROVIDER: S-EPMC11831138 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature