Effect of restrictive fluid resuscitation on severe acute kidney injury in septic shock: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Sepsis-associated hypotension or shock is a critical stage of sepsis, and a current clinical emergency that has high mortality and multiple complications. A new restrictive fluid resuscitation therapy has been applied, and its influence on patients' renal function remains unclear. The purpose of this study is to evaluate the influence of restrictive fluid resuscitation on incidence of severe acute kidney injury (AKI) in adult patients with sepsis hypotension and shock compared with usual care.

Design

Systematic review and meta-analysis using the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) approach.

Data sources

PubMed, Embase, Web of Science and Cochrane Library were searched through 1 November 2024.

Eligibility criteria

SUBMITTER: Cai XE 

PROVIDER: S-EPMC11831265 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature