Cross-sectional evaluation of host biomarkers for guiding antibiotic use in bacterial and non-bacterial acute febrile illness in low- and middle-income tropical settings.

ABSTRACT:

Objectives

To evaluate the effectiveness of 18 different host biomarkers in differentiating bacterial from non-bacterial acute febrile illness (AFI) in resource-limited settings, specifically in Brazil, Malawi and Gabon.

Design

Multinational, cross-sectional study.

Setting

The study was carried out across multiple primary healthcare facilities, including urban and rural settings, with a total of three participating centres. Recruitment took place from October 2018 to July 2019 in Brazil, May to November 2019 in Gabon and April 2017 to April 2018 in Malawi.

Participants

A total of 1915 participants, including children and adults aged 21-65 years with a fever of≤7 days, were recruited through convenience sampling from outpatient clinics in Brazil, Gabon and Malaw

SUBMITTER: Fernandez-Carballo BL 

PROVIDER: S-EPMC11831293 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature