Association between elevated serum REG Iα levels and eGFR decline in patients with chronic kidney disease: a cross-sectional study in eastern China.

ABSTRACT:

Objectives

This study aimed to investigate the relationship between serum regenerating protein Iα (REG Iα) levels and estimated glomerular filtration rate (eGFR) and to evaluate the diagnostic efficiency of REG Iα in chronic kidney disease (CKD).

Design

This is a cross-sectional study.

Setting

The study was conducted in eastern China between August 2022 and August 2023.

Participants

A total of 880 participants aged over 18 years were enrolled, with 220 non-CKD participants (111 males, 50.45%) and 660 patients with CKD (366 males, 55.45%). CKD was diagnosed based on the Kidney Disease: Improving Global Outcomes (KDIGO) 2012 guidelines. Exclusion criteria included participation in other trials, acute kidney injury, end-stage kidney disease undergoing renal replac

SUBMITTER: Huang N 

PROVIDER: S-EPMC11831304 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature