One-Pot Synthesis of Oxygen Vacancy-Rich Amorphous/Crystalline Heterophase CaWO₄ Nanoparticles for Enhanced Radiodynamic-Immunotherapy.

ABSTRACT: Radiodynamic therapy that employs X-rays to trigger localized reactive oxygen species (ROS) generation can tackle the tissue penetration issue of phototherapy. Although calcium tungstate (CaWO₄) shows great potential as a radiodynamic agent benefiting from its strong X-ray absorption and the ability to generate electron-hole (e^--h⁺) pairs, slow charge carrier transfer and fast e^--h⁺ recombination greatly limit its ROS-generating performance. Herein, via a one-pot wet-chemical method, oxygen vacancy-rich amorphous/crystalline heterophase CaWO₄ nanoparticles (Ov-a/c-CaWO₄ NPs) with enhanced radiodynamic effect are synthesized for radiodynamic-immunotherapy of cancer. The phase composition and oxygen vacancy content

SUBMITTER: Peng S 

PROVIDER: S-EPMC11831444 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature