Nanoenzymes-Integrated and Microenvironment Self-Adaptive Hydrogel for the Healing of Burn Injury and Post-Burn Depression.

ABSTRACT: Burn injuries often cause prolonged oxidative stress and inflammatory pain due to an initial increase in inflammatory responses, consequently exacerbating depressive disorders and severely impairing patients' quality of life. The primary function of traditional burn dressings is to prevent infection and facilitate tissue repair. However, these dressings are not intended for the inflammatory pain and depression that often occur during recovery. This study describes a self-healing hydrogel H@EFCP, which is designed to alleviate inflammatory pain and post-burn depression in burn injuries. This hydrogel is synthesized through the cross-linking of carboxymethyl chitosan with borate ester chelates formed from epigallocatechin gallate and 4-formylphenylboronic acid. The incorporated Prussian blue

SUBMITTER: Zhao W 

PROVIDER: S-EPMC11831452 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature