Triple-Combination Therapy with a Multifunctional Yolk-Shell Nanozyme Au@CeO₂ Loaded with Dimethyl Fumarate for Periodontitis.

ABSTRACT: Periodontitis, a chronic inflammatory disease, is the leading cause of tooth loss in adults and is one of the most prevalent and complex oral conditions. Oxidative stress induced by the excessive generation of reactive oxygen species (ROS) leads to periodontitis, which is closely associated with pathological processes, including mitochondrial dysfunction of periodontal cells and local immune dysregulation. However, current treatment modalities that target single pathological processes have limited long-term therapeutic effects. Herein, a multifunctional Yolk-Shell nanozyme, Au@CeO₂-dimethyl fumarate (DMF), which comprehensively addresses the oxidative stress-induced pathophysiological processes of periodontitis through antioxidant activity, mitochondrial maintenance, and immune

SUBMITTER: Li T 

PROVIDER: S-EPMC11831482 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature