Chromatin Topological Domains Associate With the Rapid Formation of Tandem Duplicates in Plants.

ABSTRACT: In eukaryotes, chromatin is compacted within nuclei under the principle of compartmentalization. On top of that, condensin II establishes eukaryotic chromosome territories, while cohesin organizes the vertebrate genome by extruding chromatin loops and forming topologically associating domains (TADs). Thus far, the formation and roles of these chromatin structures in plants remain poorly understood. This study integrates Hi-C data from diverse plant species, demonstrating that nuclear DNA content influences large-scale chromosome conformation and affects the finer details of compartmental patterns. These contrasting compartmental patterns are distinguished by gene-to-gene loops and validated through cytological observations. Additionally, a novel chromatin domain type associated with tandem

SUBMITTER: Ma N 

PROVIDER: S-EPMC11831494 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature