A structural equation model predicts chronic wound healing time using patient characteristics and wound microbiome composition.

ABSTRACT: Wound aetiology, host characteristics and the wound microbiome contribute to chronic wound development. Yet, there is little accounting for the relative importance of these factors to predict wound healing. Here, a structural equation model was developed to provide such an explanatory and predictive framework. Chronic wounds from 565 patients treated at a clinic practicing biofilm-based wound care were included. Patient information included DNA sequencing-based wound microbiome clinical reports corresponding to the initial clinical visit. Wound microbiome data was integrated into the SEM as a latent variable using a pre-modelling parcel optimization routine presented herein for the first time (available as R library parcelR). A microbiome latent construct associated with improved healing w

SUBMITTER: Ancira J 

PROVIDER: S-EPMC11831583 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature