Donor modulation brings all-in-one phototheranostics for NIR-II imaging-guided type-I photodynamic/photothermal synergistic cancer therapy.

ABSTRACT: Type-I photodynamic (PDT) and photothermal (PTT) synergistic therapy guided by fluorescence imaging in the near-infrared region II (NIR-II) is crucial for cancer diagnosis and treatment. Phototheranostics provide a promising system for efficient imaging-guided phototherapy, combining diagnostics with therapeutics within a single photosensitizer and avoiding the complexity of composition and low reproducibility of combination methods. Herein, we design and synthesize an all-in-one phototheranostic agent OTAB by modifying aza-BODIPY with a methoxy group substituted triphenylamine moiety, followed by the formation of nanoparticle OTAB@cRGD NPs via self-assembly with DSPE-PEG₂₀₀₀-cRGD. Structurally, the methoxy-modified triphenylamine moiety as a strong electron donor can red

SUBMITTER: Ren Y 

PROVIDER: S-EPMC11831688 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature