Targeting TUBB2B inhibits triple-negative breast cancer growth and brain-metastatic colonization.

ABSTRACT:

Background

The triple-negative subtype of breast cancer is particularly challenging to treat due to its aggressiveness with a high risk of brain metastasis, and the lack of effective targeted therapies. Tubulin beta 2B class IIb (TUBB2B), a β-tubulin isoform regulating axon guidance during embryonic development, was found to be overexpressed in various types of cancers including triple-negative breast cancer (TNBC). However, its functional roles in breast cancer or metastasis remain unclear.

Methods

To identify TUBB2B as a novel molecular target in TNBC, we performed bioinformatics analysis to assess the association of TUBB2B expression and survival of patients. RNAscope in situ hybridization was used to examine TUBB2B expression in clinical breast tumor samples. The effect

SUBMITTER: He Q 

PROVIDER: S-EPMC11831766 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature