Exploring the correlation between magnetic resonance diffusion tensor imaging (DTI) parameters and aquaporin expression and biochemical composition content in degenerative intervertebral disc nucleus pulposus tissue: a clinical experimental study.

ABSTRACT:

Objective

This study investigates the correlation between magnetic resonance diffusion tensor imaging (DTI) parameters and biochemical composition in degenerative intervertebral disc nucleus pulposus tissue, offering a potential reference for the clinical diagnosis and efficacy evaluation of intervertebral disc degeneration.

Methods

Human lumbar intervertebral disc nucleus pulposus tissue samples were collected via full endoscopic minimally invasive surgery. DTI was employed to quantitatively measure fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values in the degenerative nucleus pulposus, examining the relationship between Pfirrmann grading and these DTI parameters. Western blotting was used to detect the expression levels of aquaporin 1 (AQP1) and aqu

SUBMITTER: Chen S 

PROVIDER: S-EPMC11831834 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature