AZIN1 level is increased in medulloblastoma and correlates with c-Myc activity and tumor phenotype.

ABSTRACT:

Background

AZIN1 is a cell cycle regulator that is upregulated in a variety of cancers. AZIN1 overexpression can induce a more aggressive tumor phenotype via increased binding and resultant inhibition of antizyme. Antizyme is a protein that normally functions as an anti-tumor regulator that facilitates the deactivation of several growth-promoting proteins including c-Myc. MYC plays a critical role in medulloblastoma pathogenesis. Its amplification serves as a defining characteristic of group 3 medulloblastomas, associated with the most aggressive clinical course, greater frequency of metastases, and shorter survival times.

Methods

Medulloblastoma tissues (68 TMA, and 45 fresh tissues, and 31 controls) were stained (fluorescence and immunohistochemical) for AZIN1. Western blo

SUBMITTER: Sesen J 

PROVIDER: S-EPMC11831846 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature