Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease.

ABSTRACT:

Objective

Cerebral small vessel diseases (SVDs) are associated with cerebrovascular dysfunction, such as increased blood-brain barrier leakage (permeability surface area product), vascular pulsatility, and decreased cerebrovascular reactivity (CVR). No studies assessed all 3 functions concurrently. We assessed 3 key vascular functions in sporadic and genetic SVD to determine associations with SVD severity, subtype, and interrelations.

Methods

In this prospective, cross-sectional, multicenter INVESTIGATE-SVDs study, we acquired brain magnetic resonance imaging in patients with sporadic SVD/cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), including structural, quantitative microstructural, permeability surface area product,

SUBMITTER: Stringer MS 

PROVIDER: S-EPMC11831873 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature