Unveiling the Clinical and Imaging Signatures of Intravascular Lymphoma of the Central Nervous System: A Multicentric Cohort Study.

ABSTRACT:

Objective

Intravascular lymphoma is a rare subtype of B-cell lymphoma characterized by a clonal proliferation restricted to the lumen of small vessels. Over 50% of patients exhibit central nervous system (CNS) involvement, but diagnosis is often delayed due to the lack of distinctive features. We aimed to identify key phenotypic features for early diagnosis of intravascular lymphoma with CNS involvement through an in-depth cohort study.

Methods

We built up a multicenter retrospective cohort of 17 patients recruited in collaboration with the French Expert Network for Oculo-Cerebral Lymphomas (LOC network), and retrospectively analyzed data from medical records.

Results

In this cohort, 15 of 17 (88%) patients developed focal neurological episodes, often fluctuating and/

SUBMITTER: Berthet E 

PROVIDER: S-EPMC11831878 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature