Increased Disability Progression in rs10191329^AA Carriers with Multiple Sclerosis Is Preceded by Neurofilament Light Chain Elevations.

ABSTRACT:

Objective

We examined the impact of the rs10191329 genetic risk variant on neuroaxonal damage as measured by serum neurofilament light chain (sNfL) levels, and disability progression in people with multiple sclerosis (pwMS).

Methods

In a cohort of pwMS (n = 740), 658 participants were prospectively monitored every 2 years for less than a decade while 82 of 740 pwMS were monitored retrospectively for up to 40 years. We investigated associations between rs10191329 variants and clinical outcome, including Expanded Disability Status Scale (EDSS), disability accrual (defined by EDSS-increase of at least 1.5 for patients starting at EDSS 0, at least 1.0 EDSS-points for patients with an initial EDSS between 1 and 4.5 and at least 0.5 points for patients starting with an EDSS equal

SUBMITTER: Protopapa M 

PROVIDER: S-EPMC11831884 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature