PAGE: parametric analysis of gene set enrichment.

ABSTRACT:

Background

Gene set enrichment analysis (GSEA) is a microarray data analysis method that uses predefined gene sets and ranks of genes to identify significant biological changes in microarray data sets. GSEA is especially useful when gene expression changes in a given microarray data set is minimal or moderate.

Results

We developed a modified gene set enrichment analysis method based on a parametric statistical analysis model. Compared with GSEA, the parametric analysis of gene set enrichment (PAGE) detected a larger number of significantly altered gene sets and their p-values were lower than the corresponding p-values calculated by GSEA. Because PAGE uses normal distribution for statistical inference, it requires less computation than GSEA, which needs repeated computation o

SUBMITTER: Kim SY 

PROVIDER: S-EPMC1183189 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature