Exploring the cellular and molecular basis of murine cardiac development through spatiotemporal transcriptome sequencing.

ABSTRACT:

Background

Spatial transcriptomics is a powerful tool that integrates molecular data with spatial information, thereby facilitating a deeper comprehension of tissue morphology and cellular interactions. In our study, we utilized cutting-edge spatial transcriptome sequencing technology to explore the development of the mouse heart and construct a comprehensive spatiotemporal cell atlas of early murine cardiac development.

Results

Through the analysis of this atlas, we elucidated the spatial organization of cardiac cellular lineages and their interactions during the developmental process. Notably, we observed dynamic changes in gene expression within fibroblasts and cardiomyocytes. Moreover, we identified critical genes, such as Igf2, H19, and Tcap, as well as transcription fa

SUBMITTER: Kang J 

PROVIDER: S-EPMC11831923 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature