Analysis of transcription profiles for the identification of master regulators as the key players in glioblastoma.

ABSTRACT: Glioblastoma (GBM) is the most common malignant brain tumor with poor overall survival. Current treatment management for GBM has low efficacy, mainly due to high inter-patient heterogeneity. The transcription profiles in GBM define cell properties essential for tumor progression. We have developed an approach for the identification of master regulators (MRs) that are responsible for the gene expression changes in GBM. The approach is based on transcription factor enrichment analysis with subsequent "upstream" analysis in the signaling network. The main feature of the approach is that all calculations are performed for transcription profiles from individual samples, which allows taking into account GBM transcription heterogeneity. We identified 451 MRs that were up-regulated or down-regulat

SUBMITTER: Ivanov SM 

PROVIDER: S-EPMC11832006 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature