Unravelling the Structure of One-Electron Oxidation Products of Model Peptide Backbones Containing Methionine by IRMPD Spectroscopy: The Effect of the Neighbouring Groups.

ABSTRACT: A series of Methionine (Met) derivatives, where either the amino group and/or the carboxylic acid group is blocked by acetyl and/or methyl ester functionalities, has been investigated by Collision Induced Dissociation-tandem mass spectrometry (CID-MS²) and Infrared Multiple Photon Dissociation (IRMPD) spectroscopy. The CID-MS² experiments were performed using a Fourier-transform ion-cyclotron-resonance (FT-ICR) mass spectrometer equipped with an electrospray ionization (ESI) source. The IRMPD spectra were recorded employing a Paul type ion-trap coupled with the free-electron laser (FEL) FELIX in the fingerprint region from 600 to 2000 cm^-1. We show that the oxidation of the methionine residue with protected terminal groups induces the formation of a sulfoxi

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC11832061 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature