Regulation and function of the gill corticotropin-releasing factor system during osmoregulatory disturbances in Atlantic salmon.

ABSTRACT: While corticosteroids, including cortisol, have conserved osmoregulatory functions, the relative involvement of other stress-related hormones in osmoregulatory processes remains unclear. To address this gap, we initially characterized the gill corticotropin-releasing factor (CRF) system of Atlantic salmon (Salmo salar) and then determined: (1) how it is influenced by osmotic disturbances; (2) whether it is affected by cortisol; and (3) which physiological processes it regulates in the gills. Most CRF system components were expressed in the gills, with CRF receptor 2 (crfr2a), CRF binding protein (crfbp1 and crfbp2) and urocortin 2 (ucn2a) being the most abundant. The development of seawater tolerance in migratory juveniles (i.e. smolts) was associated with a general transcriptional upregul

SUBMITTER: Culbert BM 

PROVIDER: S-EPMC11832130 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature