Maintenance of cell wall remodeling and vesicle production are connected in <i>Mycobacterium tuberculosis</i>.

ABSTRACT: Pathogenic and nonpathogenic mycobacteria secrete extracellular vesicles (EVs) under various conditions. EVs produced by Mycobacterium tuberculosis (Mtb) have raised significant interest for their potential in cell communication, nutrient acquisition, and immune evasion. However, the relevance of vesicle secretion during tuberculosis infection remains unknown due to the limited understanding of mycobacterial vesicle biogenesis. We have previously shown that a transposon mutant in the LCP-related gene virR (virR^mut) manifested a strong attenuated phenotype during experimental macrophage and murine infections, concomitant to enhanced vesicle release. In this study, we aimed to understand the role of VirR in the vesicle production process in Mtb.

SUBMITTER: Salgueiro-Toledo VC 

PROVIDER: S-EPMC11832169 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature