T-helper cell phenotypes are repeatable, positively correlated, and associated with helminth infection in wild Soay sheep.

ABSTRACT:

Background

T-helper (Th) cells co-ordinate immune responses to ensure that infections with diverse parasites are controlled effectively. Helminth parasites such as gastrointestinal nematodes (GIN) are generally associated with T-helper type 2 (Th2) responses, while intracellular parasites are associated with Th1 responses. Although laboratory models have reported that Th1 and Th2 can be antagonistic, this has been challenged by studies of natural infections.

Methods

Between 2019 and 2022 we completed 759 captures of 538 wild Soay sheep (1-4 captures per animal) and monitored body weight, parasite egg counts, Th phenotypes, cytokines, and GIN-specific antibodies.

Results

While different Th cell counts, cytokines and antibody isotypes were generally positively correlate

SUBMITTER: Corripio-Miyar Y 

PROVIDER: S-EPMC11832277 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature