Testosterone levels at diagnosis: A key predictor of overall survival among patients with prostate cancer.

ABSTRACT:

Background and objective

The exact relationship between testosterone levels at diagnosis and prostate cancer (PCa) prognosis remains inadequately explored. The objective was to determine whether serum testosterone levels at the time of PCa diagnosis are associated with overall survival.

Patients and methods

The study cohort involved 2544 PCa patients, divided into three groups; normal (>10.4 nmol/L), grey zone (8.0-10.4 nmol/L) and low (2.0-8.0 nmol/L) serum testosterone groups. Survival outcomes were analysed using Kaplan-Meier curves and Cox regression models.

Results

The analysis revealed an increased risk of death among patients with low testosterone levels compared to those with normal levels in uni- (HR = 1.67, 95% CI: 1.37-2.05, p < 0.001) and multivaria

SUBMITTER: Jussila I 

PROVIDER: S-EPMC11832296 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature