Normal-Weight Offspring of Parents With Diet-Induced Obesity Display Altered Gene Expression Profiles.

ABSTRACT:

Objective

A Western diet is associated with obesity, and the link between parental and offsprings' obesity is unclear. Among mice, this study examined how parents' Western diets affect their male offspring's obesity risk. This study further explored whether early exposure to obesogenic diets from either parent influences offsprings' long-term weight gain.

Methods

Three-week-old C57BL6/NTac mice were assigned to a Western diet (WD) or control diet (CD), given from six to 14 weeks old. Adults from these dietary groups were then mated to create four breeding combinations: CD/CD, CD/WD, WD/CD, and WD/WD. Weight gain trajectories were studied in parents (P) and offspring (F1), along with gene expression in four tissues of male offspring. Non-linear mixed effect modeling and q-mod

SUBMITTER: Czechowski P 

PROVIDER: S-EPMC11832301 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature