Impact of fluoxetine exposure on <i>Lymnaea stagnalis</i> and its developing eggs: integrating untargeted lipidomics, targeted metabolomics, and classical risk assessment.

ABSTRACT: Pharmaceuticals such as selective serotonin reuptake inhibitors (SSRIs), are increasingly detected in aquatic environments, posing potential risks to non-target organisms, because many of those substances are widely shared neuromodulator. In this study, we investigated the effects of SSRI antidepressant, namely, fluoxetine, exposure on the freshwater snail L. stagnalis, focusing on egg development, neurochemical pathways, and lipid metabolism. Snails were exposed to a range of 51-434 µg fluoxetine L⁻¹ for 7 days, followed by analysis of survival, feeding behaviour, reproduction, and metabolomic changes in the central nervous system (CNS), albumen gland, and eggs. Although no significant effects were observed on survival or fecundity, fluoxetine exposure significantly impa

SUBMITTER: Ilyaskina D 

PROVIDER: S-EPMC11832466 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature