Generation and characterization of chicken monocyte-derived dendritic cells.

ABSTRACT:

Introduction

Dendritic cells (DCs) play a crucial role in orchestrating immune responses by bridging innate and adaptive immunity. In vitro generation of DCs from mouse and human tissues such as bone marrow and peripheral blood monocytes, has been widely used to study their immunological functions. In chicken, DCs have mainly been derived from bone marrow cell cultures, with limited characterization from blood monocytes.

Methods

The present study takes advantage of newly available chicken immunological tools to further characterize chicken monocyte-derived dendritic cells (MoDCs), focusing on their phenotype, and functions, including antigen capture and T-cell stimulation, and response to live Newcastle disease virus (NDV) stimulation.

Results

Adherent chicken

SUBMITTER: Ngantcha Tatchou E 

PROVIDER: S-EPMC11832469 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature