Identification of genes involved in energy metabolism in preeclampsia and discovery of early biomarkers.

ABSTRACT:

Background

Preeclampsia is a complex pregnancy condition marked by hypertension and organ dysfunction, posing significant risks to maternal and fetal health. This study investigates the role of energy metabolism-associated genes in preeclampsia development and identifies potential early diagnostic biomarkers.

Methods

Preeclampsia datasets from Gene Expression Omnibus were analyzed for batch correction, normalization, and differential expression. Enrichment analyses using gene ontology, Kyoto Encyclopedia of Genes and Genomes, and gene set enrichment were performed. Protein-protein interaction networks were constructed to identify key genes, and regulatory networks involving transcription factors, miRNAs, and RNA-binding proteins were established. Differential expression was

SUBMITTER: Li R 

PROVIDER: S-EPMC11832505 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature