Proteomic profiling of serum in cats with naturally occurring degenerative joint disease and co-morbid conditions.

ABSTRACT:

Introduction

Degenerative joint disease (DJD) occurs very commonly in cats and can be associated with pain. Almost 70% of cats with DJD-associated pain suffer the co-morbidity of chronic kidney disease (CKD). There are currently very limited treatment or management options. A greater understanding of the systems biology of DJD, DJD-associated pain, and CKD may contribute to identifying disease specific biomarkers and relevant targets for the development of therapeutics for the control of these conditions in cats, and help inform human pain therapeutic development.

Methods

Using mass spectrometry-based proteomic profiling of the serum of 200 highly phenotyped cats with varying burdens of DJD, pain, and CKD, we identified significant individual proteins and pathways.

Result

SUBMITTER: Lascelles BDX 

PROVIDER: S-EPMC11832531 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature