Investigating dynamic brain functional redundancy as a mechanism of cognitive reserve.

ABSTRACT:

Introduction

Individuals with higher cognitive reserve (CR) are thought to be more resilient to the effects of age-related brain changes on cognitive performance. A potential mechanism of CR is redundancy in brain network functional connectivity (BFR), which refers to the amount of time the brain spends in a redundant state, indicating the presence of multiple independent pathways between brain regions. These can serve as back-up information processing routes, providing resiliency in the presence of stress or disease. In this study we aimed to investigate whether BFR modulates the association between age-related brain changes and cognitive performance across a broad range of cognitive domains.

Methods

An open-access neuroimaging and behavioral dataset (n = 301 healthy

SUBMITTER: Schwarz J 

PROVIDER: S-EPMC11832541 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature