The METACER national cohort study of brain metastases in gastrointestinal cancers prospectively establishes prognostic factors.

ABSTRACT:

Purpose

Availability data are scarce and primarily retrospective in patients with brain metastasis (BM) from gastrointestinal (GI) cancers. The objective of this cohort was to determine prognostic factors for survival outcomes in patients with BM from GI cancers.

Methods

METACER is a national multicentric prospective cohort study which included patients with BM diagnosis during a histologically proven digestive cancer follow-up between 2010 and 2014. The primary endpoint was overall survival (OS). The secondary endpoints were Progression-Free survival (PFS), prognostic factors, and BM-free survival as time from disease diagnosis to BM diagnosis.

Results

METACER included 130 patients, with colorectal cancer (CRC) (N = 105) and eso-gastric (N = 25) cancer (EGC). The med

SUBMITTER: Randrian V 

PROVIDER: S-EPMC11832552 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature