Developmental gene expression in skull-base chordomas and chondrosarcomas.

ABSTRACT:

Purpose

 Chordomas are malignant tumors of the axial spine and skull base, and they are notorious for their poor treatment response. Differentiating these tumors from comparatively less malignant chondrosarcomas is crucial for treatment and prognostication. Both tumor types differ in their developmental origin. Chordomas are considered to be derived from notochordal remnants and chondrosarcomas from mesenchymal cells. Here, we evaluated the differential expression of developmental transcription factors in these skull base tumors.

Methods

 Histopathologically-confirmed tumor biopsies were obtained from 12 chordoma and 7 chondrosarcoma patients. Following RNA extraction, samples were submitted to real-time quantitative PCR (RT-qPCR) for the evaluation of 32 evolutionary conser

SUBMITTER: Vanderheijden C 

PROVIDER: S-EPMC11832612 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature