Primary diffuse leptomeningeal glioblastoma: a case report and literature review.

ABSTRACT:

Purpose

Glioblastoma (GBM) that presents as leptomeningeal disease (LMD) is extremely rare and fatal. Limited data are available regarding incidence, clinical presentation, and management. Prognosis is poor and no treatment is known to improve survival.

Methods and results

We present a case report of a 72-year-old female who presented with depressed sensorium, ataxia, and myelopathy. Magnetic resonance imaging (MRI) showed diffuse supratentorial and spinal LMD. There was an absence of any detectable and distinct intraparenchymal lesion on neuroaxis imaging. Biopsy of the Sylvian fissure nodule revealed GBM. Steroid therapy was ineffective for symptom relief. She opted for palliative care and expired shortly after diagnosis.

Conclusion

To our knowledge, this is the fir

SUBMITTER: Mondia MWL 

PROVIDER: S-EPMC11832630 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature