Microvascular insulin resistance with enhanced muscle glucose disposal in CD36 deficiency.

ABSTRACT:

Aims/hypothesis

Microvascular dysfunction contributes to insulin resistance. CD36, a fatty acid transporter and modulator of insulin signalling, is abundant in microvascular endothelial cells. Humans carrying the minor allele (G) of CD36 coding variant rs3211938 have 50% reduced CD36 expression and show endothelial dysfunction. We aimed to determine whether G allele carriers have microvascular resistance to insulin and, if so, how this affects glucose disposal.

Methods

Our multi-disciplinary approach included hyperinsulinaemic-euglycaemic clamps in Cd36^-/- and wild-type mice, and in individuals with 50% CD36 deficiency, together with control counterparts, in addition to primary human-derived microvascular endothelial cells with/without CD36 depletion.

Results</

SUBMITTER: Shibao CA 

PROVIDER: S-EPMC11832635 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature