Cell-cell heterogeneity in phosphoenolpyruvate carboxylase biases early cell fate priming in <i>Dictyostelium discoideum</i>.

ABSTRACT: Glucose metabolism is a key factor characterizing the cellular state during multicellular development. In metazoans, the metabolic state of undifferentiated cells correlates with growth/differentiation transition and cell fate determination. Notably, the cell fate of the Amoebozoa species Dictyostelium discoideum is biased by the presence of glucose and is also correlated with early differences in intracellular ATP. However, the relationship between early cell-cell heterogeneity, cell differentiation, and the metabolic state is unclear. To address the link between glucose metabolism and cell differentiation in D. discoideum, we studied the role of phosphoenolpyruvate carboxylase (PEPC), a key enzyme in the PEP-oxaloacetate-pyruvate node, a core junction that dictates the meta

SUBMITTER: Abe K 

PROVIDER: S-EPMC11832675 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature