Comprehensive Analyses of PANoptosome with Potential Implications in Cancer Prognosis and Immunotherapy.

ABSTRACT: Cell death resistance significantly contributes to poor therapeutic outcomes in various cancers. PANoptosis, a unique inflammatory programmed cell death (PCD) pathway activated by specific triggers and regulated by the PANoptosome, possesses key features of apoptosis, pyroptosis, and necroptosis, but these cannot be accounted for by any of the three PCD pathways alone. While existing studies on PANoptosis have predominantly centered on infectious and inflammatory diseases, its role in cancer malignancy has been understudied. In this comprehensive investigation, we conducted pan-cancer analyses of PANoptosome component genes across 33 cancer types. We characterized the genetic, epigenetic, and transcriptomic landscapes, and introduced a PANoptosome-related potential index (PANo-RPI) for eva

SUBMITTER: Cai Y 

PROVIDER: S-EPMC11832696 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature