The potential of the South African plant Tulbaghia Violacea Harv for the treatment of triple negative breast cancer.

ABSTRACT: Triple-negative breast cancer (TNBC) is difficult to treat and has a low five-year survival rate. In South Africa, a large percentage of the population still relies on traditional plant-based medicine. To establish the utility of both methanol and water-soluble extracts from the leaves of Tulbaghia violacea, cytotoxicity assays were carried out to establish the IC₅₀ values against a TNBC cell line. Cell cycle and apoptosis assays were carried out using the extracts. To identify the molecular compounds, present in water-soluble leaf extracts, NMR spectroscopy was performed. Compounds of interest were then used in computational docking studies with the anti-apoptotic protein COX-2. The IC₅₀ values for the water- and methanol-soluble extracts were determined to be 400 an

SUBMITTER: Alaouna M 

PROVIDER: S-EPMC11832780 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature