Changes in Action Tremor in Parkinson's Disease over Time: Clinical and Neuroimaging Correlates.

ABSTRACT:

Background

The various symptoms of Parkinson's disease (PD) may change differently over time as the disease progresses. Tremor usually manifests early in the disease, but unlike other motor symptoms, its severity may diminish over time. The cerebral mechanisms underlying these symptom-specific longitudinal trajectories are unclear. Previous magnetic resonance imaging (MRI) studies have shown structural changes in brain regions associated with PD tremor, suggesting that structural changes over time may define clinical trajectories.

Objectives

The aims were to investigate the longitudinal trajectory of PD tremor in relation to bradykinesia and rigidity, and assess whether tremor progression is related to structural changes in tremor-related areas.

Methods

We used data f

SUBMITTER: van den Berg KRE 

PROVIDER: S-EPMC11832800 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature