Digital Outcomes as Biomarkers of Disease Progression in Early Parkinson's Disease: A Systematic Review.

ABSTRACT: Outcomes derived from digital health technologies (DHTs) are promising candidate markers for monitoring Parkinson's disease (PD) progression. They have the potential to represent a significant shift in clinical research and therapeutic development in PD. However, their ability to track disease progression is yet to be established. This systematic review aimed to identify digital biomarkers capable of tracking early PD progression (disease duration <5 years) by reviewing longitudinal studies (minimum follow-up of 6 months). We evaluated study design and quality, population features, reported DHTs and their performance to track progression. Of 1507 records screened, 15 studies were selected, published between 2009 and 2023, with the majority coming from the last 5 years. Of the 15, 11 were o

SUBMITTER: Rabano-Suarez P 

PROVIDER: S-EPMC11832816 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature