Comprehensive analysis of basement membrane-related genes showed that NELL2 is a new therapeutic target for colorectal cancer.

ABSTRACT:

Background

The basement membrane (BM), an omnipresent extracellular matrix, plays a pivotal role as a physiological element in the process of tumor metastasis. However, given the heterogeneity of colorectal cancer (CRC), prognosis is challengingly predictive. Therefore, we aim to construct a prognostic model using BM-associated genes to assess patient prognosis and clinical drug treatment effects.

Method

The Non-negative Matrix Factorization (NMF) algorithm leverages the characteristics or categories of matrix rows and columns to achieve BMAG molecular classification and further develop a model for predicting patient prognosis. ssGSEA quantified the relatively abundance of 13 immune functionalities and 16 immune cell typologies. To predict the efficacy of immunotherapy, a co

SUBMITTER: Wang W 

PROVIDER: S-EPMC11832829 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature