Kombucha inhibits adipogenesis and promotes lipolytic activity in 3T3-L1 adipocytes.

ABSTRACT: This research was conducted to investigate the anti-obesity effects of black tea or green tea kombucha (BK, GK) and compared their compositional differences. As a result of kombucha treatment during the adipocyte differentiation process, peroxisome proliferator-activated receptor γ was significantly decreased, and CCAAT/enhancer binding protein α and adipocyte protein 2 showed a tendency to decrease with BK treatment. Oil red O staining results also demonstrated a reduction of lipid accumulation by BK treatment compared to the control. In mature adipocytes, BK significantly upregulated the gene expression of hormone-sensitive lipase and tended to increase the expression of adipose triglyceride lipase and adiponectin. Additionally, as a biomarker of lipolysis, glycerol content also marginal

SUBMITTER: Jeong AY 

PROVIDER: S-EPMC11832843 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature